DesignRandomizedDouble-blind, placebo-controlled
Now with 500 mg Cognizin® Citicoline - clinically tested for focus, recall and mental processing speed.
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CogniSHIELD® Science-Backed Brain Health® for adults 50+Sharper today.
Protected for
the years ahead.
CogniSHIELD® Advanced is built to do two things at once: support the day-to-day clarity you can actually notice, and support the long-term brain health you're protecting for decades. Now with a full 500 mg clinical dose of Cognizin® Citicoline.
Choose your supply →- From $31.49 /bottle
- Free shipping on 3 & 6 bottles
- 90-Day Money-Back Guarantee
Clinically StudiedIngredients with real results
Supports FocusAnd mental accuracy
Supports MemoryAnd recall
Daily SupportFor long-term brain health
The nearer clock
What you may notice
- Stronger memory and faster recall
- Sharper focus and better mental processing speed
- Day-to-day mental clarity you can feel
The long game
What you're building
- Support for long-term brain health pathways
- Healthy cognitive function and mental vitality as you age
- Peace of mind that you're doing the responsible thing for your brain
30+ Years ofMGH Research
500 mgCognizin®
Vegan •GMP Certified
60 Tablets30-Day Supply
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Signs you may be noticing
You know the moment.
You're in the middle of something that used to hold your full attention — and your focus quietly drifts. You pull it back. You keep going. But you noticed.
It's not dramatic. That's what makes it unsettling. It's subtle, gradual, and easy to explain away as a busy week or poor sleep.
Shifts in focus, attention, and mental energy can be part of the normal aging process — changes that often begin after 50 and can become more noticeable over the decades that follow. Which leads to the most important question you can ask about your brain:
“What can I be doing right now, while I still feel mostly like myself?”
Where the answer came from
It didn't come from a supplement company.
It came from the Neuroscience Laboratories at Massachusetts General Hospital - built on more than 30 years of research into the aging brain.
For decades, testing whether a natural compound could support the aging brain was brutally slow: one compound at a time, in animal models, a year and enormous funding per candidate. Screening the thousands of compounds found in nature was effectively impossible.
So the team built something new. They created key features of the aging brain's biology inside a laboratory model - human brain cells and mini-organoids grown in a dish - and screened thousands of natural products rapidly.
What came out of that screen wasn't one miracle ingredient. It was a combination: a small group of naturally derived compounds that did more together than any of them did alone. That synergistic base is the foundation of every CogniSHIELD® supplement.
30+Years of research by the Neuroscience Laboratories at Massachusetts General Hospital
4,000+Natural Products Tested
10+Years of testing behind the formula
3Active compounds identified through the research
But a screen like that is designed to find one thing - what supports the aging brain over the long run. It was never designed to find what you might notice next month.
That's what CogniSHIELD® Advanced adds.
Clinically Tested Cognizin® CiticolineDesignRandomized
Participants100 adultsHealthy men and women, ages 50-85
Dose500 mg / dayThe same dose in this bottle
Duration12 weeksPublished in The Journal of Nutrition
Same dose that's in this bottle. Same age range as the people reading this page. Which is also why everything below is built around 90 days.
Two clocks, one serving
Long-term protection you're choosing on purpose. Day-to-day sharpness you can pay attention to.
Long-termprotection
Day-to-daysharpness
Focus thatmatters
Supportsthe aging brain
Your 90-day Journey
What can happen over 90 days – it’s one simple commitment.
The people who report the best experiences with CogniSHIELD® didn't take it for a week. They took two tablets every morning, without gaps, for three months. Here's a picture of how that goes.
WK 1-4Build the habit
Two tablets with water, morning or early afternoon. This stretch is about consistency, not results. Some people notice clearer focus early, many notice nothing yet, and both are normal.
WK 4-8Keep going
This is where most people quit a supplement, and it's the single biggest reason they never find out whether it worked. Don't stretch the dose to make a bottle last longer — the doses on the label are the doses the research used.
WK 8-12Evaluate it
This is the window where people who notice a difference tend to notice it. Give it the full three months, then decide.
Your guarantee is still live
Bodies differ, and results will too. Give it 90 days to see what CogniSHIELD will do for you.
Choose your supply →Real stories
We'll let the people
taking it speak for themselves.
Real people. Real experiences. Real results.
★★★★★
“I am speaking sharper —
more like me.”
As I aged into my 70s, I found myself less able to find some words when speaking to friends, family and colleagues. Since taking CogniSHIELD® it feels like it's happening less and less, not more and more. I am speaking sharper, more like me, with a better command of my language now than just last month. Wow.
★★★★★
“Sharper than ever — at 81.”
A former corporate attorney who left retirement to teach 7th graders, Trish had been tracking her own cognition on Lumosity for years. When her scores started slipping, she acted. “Within three months, I saw my Lumosity scores climb back to 98. I feel sharper than ever. I think of it as putting money in the bank for my brain.”
★★★★★
“It was good to feel like
myself again.”
A former nationally ranked paddle tennis player with a famously sharp memory, Nannie struggled with lingering brain fog. “Within weeks, I began feeling the results. When I remembered a date, I’d think, ‘Yes! There’s my memory back!’ It was good to feel like myself again.”
The formula
Four actives. 1,000 mg.
Doses chosen in the lab —
not the boardroom.
Every serving — two tablets — delivers 1,000 mg of four active compounds, either derived from natural sources or identical to the dietary ingredient found in nature.
1,000 mgTotal actives per serving
4Active compounds
2Tablets daily
Cognizin® Citicoline 500 mg
Clinically tested
A patented form of citicoline, tested in human clinical trials. Cognizin® supports mental clarity through focus, reaction time, & memory.
Ipriflavone 300 mg
Foundational support
An isoflavone compound, included as a foundational part of the synergistic blend.
Quercetin blend 100 mg
Plant flavonoid
Sophora japonica L (buds) extract, standardized to provide 35 mg quercetin, with fenugreek seed powder. Included for its antioxidant properties.
Fisetin blend 100 mg
Polyphenol support
A flavonoid found in strawberries and other plants, included for its anti-inflammatory properties. Included with Fenugreek seed powder, standardized to provide 20 mg Fisetin.
Fenugreek seed powder appears in both blends for a specific job: helping the other compounds be absorbed, so the doses on the label are doses your body can use.
Full label disclosure
Nothing hidden behind
a “proprietary blend”.
Supplement Facts
Serving Size: 2 tablets
Servings Per Container: 30
Amount Per Serving%DV
- Citicoline (as Cognizin®)
- 500 mg
- *
- Ipriflavone
- 300 mg
- *
- Quercetin blend
- 100 mg
- * Sophora japonica L (buds) extract (standardized to provide 35 mg quercetin), Fenugreek seed powder
- Fisetin blend
- 100 mg
- * Fenugreek seed powder, Rhus succedanea (stem) extract (standardized to provide 20 mg fisetin)
* Daily Value (DV) not established.
Other Ingredients: Sunflower lecithin, sunflower oil, silicon dioxide, isomalt, microcrystalline cellulose, low substituted hydroxypropyl cellulose, dicalcium phosphate dihydrate, dicalcium phosphate anhydrous granular, magnesium stearate, yellow (for color).
Tested for potency, safety and purity
Every ingredient, every batch.
Certified Good Manufacturing Practices
Manufactured in a GMP-certified facility.
Vegan
No animal-derived ingredients.
Specifically designed for adults 50+
Formulated for the aging brain, not general wellness.
Two tablets daily • One bottle per month
Simple routine, no timing rules to remember.
Healthy lifestyle, healthy brain
A supplement is one part of the answer. Here's the rest.
Rudolph E. Tanzi, PhD, the acclaimed Massachusetts General Hospital neuroscientist, developed the formula for CogniSHIELD® Advanced. Dr. Tanzi’s groundbreaking discoveries are making brain fitness a priority by helping maintain brain health and mental acuity. Dr. Tanzi’s SHIELD protocol provides pioneering lifestyle interventions that can help improve brain health today.
Sleep
Aim for 7–8 hours a night. Sleep is when the brain clears out waste material.
Handle stress
Meditation, time outdoors, a hobby you love — whatever reliably takes your mind off the past and the future.
Interact with others
Stay socially active. Regular contact with people you feel close to and can confide in matters more than most people expect.
Exercise
Aim for at least 150 minutes a week. Start small and build.
Learn new things
Challenge your brain with something genuinely unfamiliar — a language, an instrument, a skill you're bad at.
Diet
Eat a plant-rich diet, and go easy on sugary, salty and processed foods.
Straight answers
Questions worth asking.
Clear answers to the questions people ask most about CogniSHIELD® Advanced.
1What makes this different from the original CogniSHIELD®?
CogniSHIELD® Advanced is a reformulation, not a repackaging. It delivers 500 mg of Cognizin® Citicoline per serving — a patented form of citicoline tested in human clinical trials — alongside the synergistic base discovered in the Neuroscience Laboratories at Massachusetts General Hospital. The formula has been rebuilt around it: 1,000 mg of active compounds per serving, in tablet form. Advanced replaces the original entirely.
2What is Cognizin®, and why 500 mg?
Cognizin® is a patented form of citicoline from Kyowa Hakko — the only citicoline tested in healthy adults and adolescents in human clinical trials, and one of the most clinically researched nootropic ingredients for focus and attention. 500 mg per serving is the full dose that clinical research is built on, rather than a token amount included for the label.
3How long until I notice something?
There's no guarantee, and bodies differ. Some people notice clearer focus within the first few days. But across the stories we hear, the common thread is that using it for at least 60 to 90 days is where people report the most noticeable results, because CogniSHIELD® Advanced is designed for steady support with daily use.
4Do I still need to change my lifestyle?
A supplement is one part of the picture, not the whole of it. Living a SHIELD lifestyle — sleep, handling stress, interacting with others, exercise, learning new things and diet — can help, along with taking CogniSHIELD® Advanced daily.
5Is it safe? How is it made?
Every ingredient is either derived from a natural source or identical to a dietary ingredient found in nature, then tested for potency, safety and purity. CogniSHIELD® Advanced is manufactured under Certified Good Manufacturing Practices and is completely vegan. As with any supplement, consult your healthcare provider before use if you're pregnant, nursing, taking medications, or managing a health condition.
6What if it doesn't work for me?
Every order is covered by our 90-Day Money-Back Guarantee. Take CogniSHIELD® Advanced daily for a full 90 days. If you don't feel it's right for you, contact us with your order number and we'll refund you.
Still have a question? Call us on 1-844-482-6464 and a person will answer it.
Sharper today.
Protected for the
years ahead.
Give it 90 days and let your own mind be the judge —
backed by our 90-Day Money-Back Guarantee.
Call 1-844-482-6464
From $31.49/bottle- Free shipping on 3 & 6 bottles
- 90-Day Money-Back Guarantee
From $31.49/bottle